Basic Information
VIS ID
TVIS10010712
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
268
Orient
+
Integrated sequence
ACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTT| |CTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGG
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
39286931/38796291 (Hg38)
End
39286931/38796291 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA19A
Nearest miRNA
hsa-mir-10395/Upstream/3450664; hsa-let-7e/Downstream/613332;
Nearest TSS
ENST00000633603/Upstream/5763; ENST00000594558/Downstream/7360;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3269, chr19-CpG: 35/Downstream/35333
Nearby gene
LGALS7B(-4537) ; LGALS4(+5380) ;
Upstream sequence
ttctgcccattttaaattggatttttAAAAGGTGTTATATAATCTTATCCATAAATATGTGTATAATTCTAAATGATATTTAttttttaatttttatttt
Downstream sequence
tgagatggggtctcactatgctgcccaggctggtctcaaactcccaggttcaaacagtcttcccaccttagcctcccaagtagctaggattacaggcatc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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