Basic Information
VIS ID
TVIS10010715
Fusion event
HBV-APOC4-APOC2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1950
Orient
-
Integrated sequence
TTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTC| |TCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCAC
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
45446218/44942961 (Hg38)
End
45446218/44942961 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA19A
Target gene
APOC4-APOC2
Nearest miRNA
hsa-mir-10395/Upstream/184240; hsa-let-7e/Downstream/493693;
Nearest TSS
ENST00000633603/Upstream/687; ENST00000585786/Downstream/3021;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/33618, chr19-CpG: 64/Downstream/11995
Upstream sequence
gggattctcctgcctcagtcttcagagtatttgggactacagacacacgccaccatgcctggctaattttttttttttgagacggagtctcgctctgtta
Downstream sequence
cccaggctggagtgcagtggcgtgatcttggctcactgcaacgtccgcctcccgggttcacgccattctcctgcctcagcctcccgagtagctgggacta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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