Basic Information
VIS ID
TVIS10010722
Fusion event
HBV-LOC730076 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3172
Orient
-
Integrated sequence
AAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGC| |CATGCAGTGG
Host Sequence
Chromosome
chr2
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
132845618/132088045 (Hg38)
End
132845618/132088045 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LOC730076
Nearest miRNA
hsa-mir-1285-2/Upstream/596809; hsa-mir-10b/Downstream/168921;
Nearest TSS
ENST00000437798/Upstream/93884; ENST00000622084/Downstream/64693;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/49234, chr2-CpG: 23/Downstream/165994
Nearby gene
C2orf27B(-286384) ; ANKRD30BL(+59546) ;
Upstream sequence
AGCCAGACCTGGTCACCTGTCTGGAGCAAAGGAAAAAGCCATGGAGTATGAAGCACCCAGGTAGGTGAAAGCGAATGAAGAAGAGGATGACATAGATGAG
Downstream sequence
GCATCCAAAGGCCAAGAGGAACCCGGACTTTAACATGTAATTTGGGAAGCTGTGCTCCAGTGGAAATCCTTTCTGAGAAGCCTGGGTTTTTTCACTTGTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate