VISDB Viral Integration Site DataBase

VIS ID

TVIS10010723

Fusion event

HBV-LRP1B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

449

Orient

-

Integrated sequence

GTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCT| |GGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACC

Chromosome

chr2

Cytoband

q22.1

Reference genome

Start

End

141290098/140532529 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-200c-3p ; hsa-mir-106b-3p ; hsa-mir-5692a

Nearest miRNA

hsa-mir-128-1/Upstream/4867051; hsa-mir-10b/Downstream/54097;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/1751449, chr2-CpG: 58/Downstream/1597626

Nearest cancer related gene

LRP1B(TSG, No orient, 0)

Upstream sequence

ctctatcaccaagctggagtgcagtgatgtgatctcaactcactgcaaccttcacctctcgggttcaagcgattctcctgcctcagcatcccgagtagct

Downstream sequence

gggactacaggcgagtgcaaccacgcctggctaatttttgtatttttagtcgagatggggtttcaccatgttgaccaggatggtctcaatctcttgacct