Basic Information
VIS ID
TVIS10010729
Fusion event
HBV-LOC100130452 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1755
Orient
-
Integrated sequence
ATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGAT| |TAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCAT
Host Sequence
Chromosome
chr2
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
197569711/196704987 (Hg38)
End
197569711/196704987 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
LOC100130452
Nearest miRNA
hsa-mir-10b/Upstream/7571876; hsa-mir-1244-1/Downstream/10078247;
Nearest TSS
ENST00000437798/Upstream/3878; ENST00000461825/Downstream/8112;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/65153, chr2-CpG: 31/Downstream/94501
Upstream sequence
tttttatggctgcatagtattgaatggtgtatatgtgccacattttcttaatccagtctatcatctatgaacattttgggttggttccaagtctttgcta
Downstream sequence
ttgtgaatagtgccgcaataaacatacatgtgcatgtgtctttatagtagcatgatttataatcctttgggtatatacccagtaatgggatggctgggtc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate