Basic Information
VIS ID
TVIS10010747
Fusion event
HBV-BABAM2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1790
Orient
-
Integrated sequence
ACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGC| |ATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGG
Host Sequence
Chromosome
chr2
Cytoband
p23.2
Reference genome
GRCh37/hg19
Start
28525537/28302670 (Hg38)
End
28525537/28302670 (Hg38)
Orient
-
Location type
Intronic
Target gene
BABAM2
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-1301/Upstream/306221; hsa-mir-10b/Downstream/4229483;
Nearest TSS
ENST00000437798/Upstream/408050; ENST00000460736/Downstream/7789;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/411773, chr2-CpG: 302/Downstream/87427
Upstream sequence
aagcctttttgtagacatgtgttttcctttcttcaggtaaatacttgggagtgggagtacatatgtgattaactttatgagaaggtgacaagctttttta
Downstream sequence
aagtggtatcggtttaccctcccatcagcaatatgccagggttccagttgcttcacattctcaccaacacatcctattgtcagtctttttaaattgtacc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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