Basic Information
VIS ID
TVIS10010748
Fusion event
HBV-HNRNPA1P66 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1561
Orient
-
Integrated sequence
CTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCC| |TTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGA
Host Sequence
Chromosome
chr2
Cytoband
p15
Reference genome
GRCh37/hg19
Start
63979295/63752161 (Hg38)
End
63979295/63752161 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
HNRNPA1P66
Nearest miRNA
hsa-mir-1301/Upstream/1546244; hsa-mir-10b/Downstream/588586;
Nearest TSS
ENST00000437798/Upstream/146351; ENST00000484142/Downstream/75682;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/129131, chr2-CpG: 87/Downstream/88597
Nearby gene
MDH1(-144965) ; UGP2(+88803) ;
Upstream sequence
GGTGAAGCACTATCCACCTCTTGTTTTGGCAGGGCTTTCCTAACTTCACAGGTGTGGCCATTCACACGACGGTATTTCTGAATGACAATTTTATCCACGG
Downstream sequence
AGTCATGGTCATCAAAGCTTATAAAGACAAAGCTCCTTTTTTTTTTTGCCACTGCCTCAATCAGTCATAATTTCAATCACTTCAATTTTTCCATACTGTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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