Basic Information
VIS ID
TVIS10010753
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
680
Orient
-
Integrated sequence
CTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTT| |ACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATC
Host Sequence
Chromosome
chr20
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
16889188/16908543 (Hg38)
End
16889188/16908543 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/6258848; hsa-mir-1-1/Downstream/1562072;
Nearest TSS
ENST00000382410/Upstream/44395; ENST00000470007/Downstream/317564;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/178073, chr20-CpG: 36/Downstream/317340
Nearby gene
OTOR(-156379) ; PCSK2(+317564) ;
Upstream sequence
atctcatttgtcaattttggcttttgttgccattgcttttggtgttttagacatgaagtccttgcccatgcctatgtcctgaatggtattgtctaggttt
Downstream sequence
tcttctagggtttttatggttttaagtctaacatttaagtcttaatccatcttgaattaatttttgtataaggtgtaaggaagggatccagtttcagttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate