Basic Information
VIS ID
TVIS10010754
Fusion event
HBV-MIR663AHG integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2267
Orient
+
Integrated sequence
TCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTT| |CGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCC
Host Sequence
Chromosome
chr20
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
26189093/26208457 (Hg38)
End
26189093/26208457 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
MIR663AHG
Nearest miRNA
hsa-mir-103a-2/Upstream/179; hsa-mir-1-1/Downstream/5398729;
Nearest TSS
ENST00000382410/Upstream/20019; ENST00000400552/Downstream/4080022;
Nearest CpG islands
chr20-CpG: 198/Target, None/Upstream, None/Downstream
Upstream sequence
CAACGCCAGGGCCACATCGCTCGTGATTCTCGTCCATCCTCCGACCCGGTCCCGCTCCGGGAGACCGGCGCGCCCCCACCGTGGGACGCTTTCCCAGGGC
Downstream sequence
CAGGCGGCCCGACCACGTGCCACGCAAACGCCGTCGTCCGCACCGGTCGCGACTCGGCAAGGGAGCGGGCGGAGAGCTGACTCGCGGCGGAGGGGGGTCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate