Basic Information
VIS ID
TVIS10010763
Fusion event
HBV-chr22 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3172
Orient
-
Integrated sequence
AAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGC| |CATGCAGTGG
Host Sequence
Chromosome
chr22
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
16635653/15342308 (Hg38)
End
16635653/15342308 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7a-3/Downstream/2421872;
Nearest TSS
ENST00000624155/Upstream/37752; ENST00000252835/Downstream/185851;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/2526674, chr22-CpG: 65/Downstream/168495
Nearby gene
OR11H1(-185849) ; CCT8L2(+435995) ;
Upstream sequence
AGCCAGACCTGGTCACCTGTCTGGAGCAAAGGAAAAAGCCATGGAGTATGAAGCACCCAGGTAGGTGAAAGCGAATGAAGAAGAGGATGACATAGATGAG
Downstream sequence
ACATCCAAAGGCCGAGAGGAACCCGGACTTTTACATGTGATGTGGGAAGCTGTGCTCCAGTGGAAATCGTTTCTGAAAAGCCTGGGTTTTTTCACTTGTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate