Basic Information
VIS ID
TVIS10010778
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|
Start
2510
Orient
+
Integrated sequence
CGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTAC| |CTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGT
Host Sequence
Chromosome
chr3
Cytoband
q26.2
Reference genome
End
169926683/170208895 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/1656946; hsa-mir-1224/Downstream/214208;
Nearby gene
PHC3(-27146) ; PRKCI(+13537) ;
Nearest cancer related gene
PHC3(TSG, -27146) ; PRKCI(OG, +13537) ;
Upstream sequence
cattactttcagggaaccacaatgataattacagcttctcaacacaattatggcgaaaaaaagacaaaaaaaactacaattcaaaataacaaaagcaaaa
Downstream sequence
TCTCCTTTTTATGACATTATCACATGCTCTGTGTAACCGCTGAAAAATGCTGGGTTAAGGGTGACAGGCTTCTGTGAAGTTGAGGGTTTAAGTAAGCACC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate