Basic Information
VIS ID
TVIS10010779
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1802
Orient
-
Integrated sequence
GCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCT| |GCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGC
Host Sequence
Chromosome
chr3
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
169926702/170208914 (Hg38)
End
169926702/170208914 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/1656965; hsa-mir-1224/Downstream/214189;
Nearest TSS
ENST00000440867/Upstream/27165; ENST00000488541/Downstream/13451;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/27076, chr3-CpG: 64/Downstream/13455
Nearby gene
PHC3(-27165) ; PRKCI(+13518) ;
Nearest cancer related gene
PHC3(TSG, -27165) ; PRKCI(OG, +13518) ;
Upstream sequence
gtgagaaatcactttgtatgaattatgctggcagaggtgaagaagcttgacaatagaaagtgtgggcaaggatattaatcagtagcaactctattgctgg
Downstream sequence
TCACATGCTCTGTGTAACCGCTGAAAAATGCTGGGTTAAGGGTGACAGGCTTCTGTGAAGTTGAGGGTTTAAGTAAGCACCATTTTAAGTACAGCAGAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate