Basic Information
VIS ID
TVIS10010784
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1741
Orient
+
Integrated sequence
GCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAG| |TTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAAT
Host Sequence
Chromosome
chr3
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
32056950/32015458 (Hg38)
End
32056950/32015458 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/853671; hsa-let-7g/Downstream/490825;
Nearest TSS
ENST00000440867/Upstream/33684; ENST00000429432/Downstream/62122;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/33586, chr3-CpG: 101/Downstream/90876
Nearby gene
ZNF860(-23722) ; GPD1L(+91053) ;
Upstream sequence
TCAAGATTAATAAATAGTCCTTAGAGAGTGTACTTTTGACAGATAAACAGCTATGGAATCTCTAATAAGCACAAACATATTTTGCATTTGATATTAACTT
Downstream sequence
ttaaagacttaaatgttagacctaaaaccataaaaactctagaagaaaacctgggcaataccattcaggacataggcataggcaaggacttcatgtctaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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