VISDB Viral Integration Site DataBase

VIS ID

TVIS10010788

Fusion event

HBV-FHIT integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1971

Orient

+

Integrated sequence

CTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTC| |TTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGC

Chromosome

chr3

Cytoband

p14.2

Reference genome

Start

End

61234779/61249105 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-143-3p ; hsa-mir-217 ; hsa-mir-331-3p ; hsa-mir-625-5p

Nearest miRNA

hsa-let-7g/Upstream/631235; hsa-mir-12124/Downstream/5976359;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/2198887, chr3-CpG: 48/Downstream/1827

Nearest cancer related gene

FHIT(TSG, No orient, 0)

Upstream sequence

ctaaaataatcaaaagggtcagaatctagtttaaagagagtttattcaaacacaaagttcgaggatagactatacaagaaaaagagattacaaaaaatgg

Downstream sequence

GTGGCCTTGAAAGAGCAAATTAGAGGAGAAACCATTATCTAAAGAGCTACACATCTGGTGTTCCTGCTAGCTGACTGCtggtggaatgaaaataaccctg