Basic Information
VIS ID
TVIS10010791
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1854
Orient
+
Integrated sequence
TTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCA| |TGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGT
Host Sequence
Chromosome
chr3
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
77730747/77681596 (Hg38)
End
77730747/77681596 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/1943233; hsa-mir-12124/Downstream/1826291;
Nearest TSS
ENST00000440867/Upstream/46671; ENST00000461186/Downstream/365198;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/583348, chr3-CpG: 49/Downstream/1337317
Nearby gene
ROBO2(-31633) ; ROBO1(+915641) ;
Nearest cancer related gene
ROBO1(TSG, +915641) ;
Upstream sequence
ccaattgtgtcctgttgcaaaagaaaacagatacttatttgcacttatgcaaataactatattgcataaattaggaatactcaattagtttgaccatagg
Downstream sequence
tgcttgacagttaacaacttgtctctgcactacttggcttttgccggggctggggcagaccaagaactgggagctgaagtcttgtttagtgtgacatgga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate