Basic Information
VIS ID
TVIS10010797
Fusion event
HBV-LOC105377387 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1218
Orient
-
Integrated sequence
TTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGG| |TCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGC
Host Sequence
Chromosome
chr4
Cytoband
q26
Reference genome
GRCh37/hg19
Start
117975613/117054457 (Hg38)
End
117975613/117054457 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105377387
Nearest miRNA
hsa-mir-12113/Upstream/2397603; hsa-mir-1305/Downstream/8452802;
Nearest TSS
ENST00000502981/Upstream/539311; ENST00000420701/Downstream/31119;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/128091, chr4-CpG: 35/Downstream/30925
Nearby gene
MIR1973(-754689) ; TRAM1L1(+29097) ;
Upstream sequence
tccaccaaagttgattgcatgttattccattccattccattccatttcattcaattctattccattccattcctttccactcgggttgattccattccat
Downstream sequence
AATTTCTGTTGATTATGCATCCTAGTTAAACAATCATCCTTTGATTCTCTACAGAACTCATTATGTATACCACTAGATACTTATAATTTACTATCTACTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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