Basic Information
VIS ID
TVIS10010801
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
405
Orient
-
Integrated sequence
CCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTC| |CTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCA
Host Sequence
Chromosome
chr4
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
157970470/157049318 (Hg38)
End
157970470/157049318 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/4512802; hsa-mir-1305/Downstream/2079484;
Nearest TSS
ENST00000502981/Upstream/77924; ENST00000515642/Downstream/26739;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/77184, chr4-CpG: 78/Downstream/26696
Nearby gene
PDGFC(-77924) ; GLRB(+26807) ;
Upstream sequence
ccagaatactcctgccgtggtctgaatgtttgtccctcacataggattccagaacattcatgctggggtctcaatgtttcccttaacataggatttcaga
Downstream sequence
ccgtttgtgctaagaaagcaccatgtgccacatctaggaatactgctctgacttttataccaggtaacacaagagtcttccacctttgaataggacccaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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