Basic Information
VIS ID
TVIS10010818
Fusion event
HBV-LINC02358 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1820
Orient
-
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
55722219/54856053 (Hg38)
End
55722219/54856053 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4B
Target gene
LINC02358
Nearest miRNA
hsa-mir-12113/Upstream/2143306; hsa-mir-1243/Downstream/6066566;
Nearest TSS
ENST00000502981/Upstream/10485; ENST00000509711/Downstream/87577;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/196923, chr4-CpG: 64/Downstream/269182
Nearby gene
KIT(-115338) ; KDR(+222207) ;
Upstream sequence
ggatgagggcaccaggttggatttctagcccagtgtaagtgggcatggagagccaaCAGGCCATCTGGTGAGCTCTCTTTGTGGAGCTGGGTTACCACTG
Downstream sequence
ATACTTTTCAATTTTCAAATGTTTTTGTAAATCTCCAGGAGATAGCAGTTTGCTGAGTTGGCAAATGGGCAGCACTTGGGCAGATAATGGGCTGAGCTTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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