Basic Information
VIS ID
TVIS10010823
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1829
Orient
+
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
End
64979906/64114188 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/3191504; hsa-mir-1243/Downstream/2162636;
Nearby gene
TECRL(+164271) ;
Upstream sequence
CAGAAGCTAGAGAGGGGCACAATCAAATTTGATGCTAGAAGGCAAATTTTCATTCAGATTCTTATGtgtggtagatggcaaaaatggccacgaattcttc
Downstream sequence
AAGTATTTTAGGAGAAAACATATGAGAGATTAGGAAGCTTCTTTTAGCTCTTTCTTGATATGCTTTTTGATATCGTGGTCACAGAAAAGGCATCCTGGCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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