Basic Information
VIS ID
TVIS10010832
Fusion event
HBV-LOC101927078 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1599
Orient
+
Integrated sequence
CGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTC| |TGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTT
Host Sequence
Chromosome
chr5
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
113868090/114532393 (Hg38)
End
113868090/114532393 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC101927078
Nearest miRNA
hsa-mir-10397/Upstream/4018478; hsa-mir-103a-1/Downstream/1723350;
Nearest TSS
ENST00000502646/Upstream/45691; ENST00000506392/Downstream/43648;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/168895, chr5-CpG: 160/Downstream/636727
Nearby gene
KCNN2(-35893) ; TRIM36(+592369) ;
Upstream sequence
TGAGGCCATACTGTTCAATTAGCAACTGGAAAATTAAAATCTTTCCCACCCTGTAAGAGCCCTACGACACTACAGAAGGGCTCAAATACATTTTAAAAGT
Downstream sequence
tattgtctttgaagcaattctgaatgggagttcactcatgatttggctctctgtttgtctgttattggtgtataagaacacttgtgatttttgcacactg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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