Basic Information
VIS ID
TVIS10010834
Fusion event
HBV-LOC105374655 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2913
Orient
-
Integrated sequence
GTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAG| |CCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGG
Host Sequence
Chromosome
chr5
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
12527884/12527772 (Hg38)
End
12527884/12527772 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105374655
Nearest miRNA
hsa-mir-10397/Upstream/2049627; hsa-mir-103a-1/Downstream/2298157;
Nearest TSS
ENST00000502646/Upstream/623729; ENST00000505877/Downstream/46865;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/623181, chr5-CpG: 46/Downstream/267088
Nearby gene
CTNND2(-623774) ; LINC01194(+47085) ;
Upstream sequence
caatctcggctcactgccagctccgcctcccgggttcacgccattctcctgcctcagcctcccaagcagctgggactacaggcgcccaccaccatgcccg
Downstream sequence
TCTAAATCTTCTTTTTTTTTTTTAAGATTAAATTAGTTTTACCCAATTTTTACCTACAAATTTAAATCGTAGATAATTGTAGAAGTCTTTTTTCTTAAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate