Basic Information
VIS ID
TVIS10010844
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1916
Orient
+
Integrated sequence
TGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCC| |TTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTAT
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
1301357/1301242 (Hg38)
End
1301357/1301242 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-4635/Upstream/238268; hsa-mir-10397/Downstream/8068;
Nearest TSS
ENST00000502646/Upstream/6173; ENST00000605200/Downstream/20587;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/5387, chr5-CpG: 18/Downstream/33720
Nearby gene
TERT(-6195) ; MIR4457(+8068) ;
Upstream sequence
tctggccccagccatctctccagcctcatttctgGTGACTCCCAGATCTGGCCCCAGCCATGTCTCTAGACTCCAAACTTATTCCTTATAATGCTCCCAC
Downstream sequence
ttctggaggaaatcaccaccatttttcgtttcaggattcatacagattaagtttaaccaaacacgaacacacaatcgaaaatctccaagcacacaagaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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