VISDB Viral Integration Site DataBase

VIS ID

TVIS10010851

Fusion event

HBV-OTULIN integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1829

Orient

+

Integrated sequence

GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT

Chromosome

chr5

Cytoband

p15.2

Reference genome

Start

End

14669475/14669366 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-29c-3p ; hsa-mir-155-5p ; hsa-mir-32-5p ; hsa-mir-96-5p ; hsa-mir-16-5p ; hsa-let-7a-5p ; hsa-mir-3190-5p ; hsa-mir-3675-3p ; hsa-mir-3926 ; hsa-mir-4684-5p ; hsa-mir-548aa ; hsa-mir-548ap-3p ; hsa-mir-548as-3p ; hsa-mir-548at-3p ; hsa-mir-548ay-3p ; hsa-mir-548c-3p ; hsa-mir-548s ; hsa-mir-548t-3p ; hsa-mir-6771-3p ; hsa-mir-6849-3p ; hsa-mir-1285-3p ; hsa-mir-196a-3p ; hsa-mir-3187-5p ; hsa-mir-3667-5p ; hsa-mir-371a-5p ; hsa-mir-371b-5p ; hsa-mir-372-5p ; hsa-mir-373-5p ; hsa-mir-451b ; hsa-mir-4696 ; hsa-mir-508-5p ; hsa-mir-5189-5p ; hsa-mir-612 ; hsa-mir-616-5p ; hsa-mir-6501-3p ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6720-5p ; hsa-mir-6860 ; hsa-mir-766-3p ; hsa-mir-939-3p

Nearest miRNA

hsa-mir-10397/Upstream/4191221; hsa-mir-103a-1/Downstream/156563;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/4260, chr5-CpG: 21/Downstream/201916

Upstream sequence

GTGCAGGGACGCCAGCGAGGGCCCCAGCGGAGAGAGGTCGAATCGGCCTAGGCTGTGGGGTAACCCGAGGGAGGGGCCATGATGTGGAGGCCCTGGGAAC

Downstream sequence

aaaaaagaaaaTAGGTAAATATTGTTTAATAGGAACTTGAAAATATACACTTTAAAATAATGCCATAGTGCAAAACTAAGTATTTTCTAACTAGGAATTG