Basic Information
VIS ID
TVIS10010856
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
655
Orient
-
Integrated sequence
TATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCT| |CAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTA
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
51463769/52167935 (Hg38)
End
51463769/52167935 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5H
Nearest miRNA
hsa-mir-10397/Upstream/13610374; hsa-mir-103a-1/Downstream/1783569;
Nearest TSS
ENST00000502646/Upstream/158120; ENST00000506949/Downstream/619961;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/768417, chr5-CpG: 34/Downstream/620177
Nearby gene
ISL1(-773206) ; PELO(+620005) ;
Upstream sequence
AAAGTATCATTCCTTCCTCCACAGGAGTGAGAGGAACTCCTCTGCCCCTGGGGGGGGATAGGGAAGGGGCTCAATCCCAGTAGAGTAGGAGGGATGGACT
Downstream sequence
tcttctagggtttttatggttttaggtgtaacatgtaagtctttaatccattttgaattaatttttgtataaggtgcaaagaggggatccagtttcagct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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