Basic Information
VIS ID
TVIS10010861
Fusion event
HBV-ADGRV1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1817
Orient
+
Integrated sequence
TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
90128900/90833083 (Hg38)
End
90128900/90833083 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADGRV1
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-10a-5p
Nearest miRNA
hsa-mir-10397/Upstream/816363; hsa-mir-103a-1/Downstream/2787613;
Nearest TSS
ENST00000502646/Upstream/11028; ENST00000505845/Downstream/7863;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/273944, chr5-CpG: 36/Downstream/447447
Upstream sequence
accgactctagaactgctgaacactgtagaccttcctttcagataattgcacatgcaaacaaactccaactagttgcagattattttaataccccgtaat
Downstream sequence
gagtcttttgtagttccatttaagattatttttcctatttctgtgaagaatgtcattggcattttgataaggattgtgttgaatctgtagattgctttgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate