Basic Information
VIS ID
TVIS10010863
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
-
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr6
Cytoband
q16.3
Reference genome
GRCh37/hg19
Start
105314855/104866980 (Hg38)
End
105314855/104866980 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/5742284; hsa-mir-1202/Downstream/1917145;
Nearest TSS
ENST00000381078/Upstream/7061; ENST00000635857/Downstream/69636;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/6939, chr6-CpG: 181/Downstream/73335
Nearby gene
HACE1(-7061) ; LIN28B-AS1(+69314) ;
Nearest cancer related gene
HACE1(TSG, -7061) ;
Upstream sequence
gaccaaaatcattctaaggacacttaatacagcaaaggacaggtacatgtaatctttaaaataacttacaaagatcaaaatggaacaaagcaaacgtgaa
Downstream sequence
atttcgctcttgtcacccaggctggagtgcaatggtgcaatcttggctcactgcaatctccgcctcctgggttcaagtgattctcctgtcacagcctcct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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