Basic Information
VIS ID
TVIS10010867
Fusion event
HBV-LOC105377998 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
680
Orient
-
Integrated sequence
CTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTT| |ACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATC
Host Sequence
Chromosome
chr6
Cytoband
q22.33
Reference genome
GRCh37/hg19
Start
128999479/128678334 (Hg38)
End
128999479/128678334 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105377998
Nearest miRNA
hsa-mir-10398/Upstream/2193621; hsa-mir-1202/Downstream/3113838;
Nearest TSS
ENST00000381078/Upstream/157660; ENST00000466230/Downstream/204807;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/97554, chr6-CpG: 29/Downstream/251634
Nearby gene
PTPRK(-157609) ; LAMA2(+204807) ;
Upstream sequence
tggaacCATTAAAAAATATGACTAGCACATTGGATCCAAAATAAATTGGCCCTTATGACCCTGAATGACACGTTGTTTTTTTTCTTCAGTGAACTATTGT
Downstream sequence
acctagacaataccattcaggacataggcatgggcaaggacttcatgtctaaaacaccaaaagcaatggcaacaaaagccaaaattgaccaatgggatct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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