Basic Information
VIS ID
TVIS10010869
Fusion event
HBV-LOC105378027 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1823
Orient
-
Integrated sequence
TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA
Host Sequence
Chromosome
chr6
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
140876450/140555313 (Hg38)
End
140876450/140555313 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105378027
Nearest miRNA
hsa-mir-10398/Upstream/349987; hsa-mir-1202/Downstream/128501;
Nearest TSS
ENST00000381078/Upstream/468631; ENST00000565399/Downstream/297611;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1179872, chr6-CpG: 46/Downstream/1533023
Nearby gene
MIR3668(-349987) ; MIR4465(+128501) ;
Upstream sequence
ttcagaaattttatgaagttcctaggaattggtcaataaccttgatctccctgatacgtcctggtataatgtagtcagtcataattctatgatttaaatt
Downstream sequence
tcaccgtattggccaggatggtctcaatctcctgacctcatgatccacgagggatcccagccttggcctcccaaagtgctgggattacaggcatgagcca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate