Basic Information
VIS ID
TVIS10010874
Fusion event
HBV-TSBP1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1272
Orient
-
Integrated sequence
CTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATA| |CTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTT
Host Sequence
Chromosome
chr6
Cytoband
p21.32
Reference genome
GRCh37/hg19
Start
32270914/32303137 (Hg38)
End
32270914/32303137 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
TSBP1
Nearest miRNA
hsa-mir-1236/Upstream/123261; hsa-mir-10398/Downstream/446775;
Nearest TSS
ENST00000381078/Upstream/40435; ENST00000644884/Downstream/68735;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/106531, chr6-CpG: 33/Downstream/218828
Upstream sequence
gatgaaggattttatctccttagctcatctaggtctgggttcttgtcttgtctcatgaccaggaaaaatcaggcacgtggacactcgaagagtgagtgga
Downstream sequence
gggtggtttacttgttgtcttctctgattgaaatattcccccctcagatattgcctggctaattctctcacctatttcatgttccatctagtagttatag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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