VISDB Viral Integration Site DataBase

VIS ID

TVIS10010882

Fusion event

HBV-MET integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|

Start

2922

Orient

+

Integrated sequence

CATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAG| |CAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCC

Chromosome

chr7

Cytoband

q31.2

Reference genome

Start

End

116316204/116676150 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-206 ; hsa-mir-34c-5p ; hsa-mir-34b-5p ; hsa-mir-34a-5p ; hsa-mir-1-3p ; hsa-mir-199a-3p ; hsa-mir-23b-3p ; hsa-mir-34b-3p ; hsa-mir-562 ; hsa-mir-30a-5p ; hsa-mir-340-5p ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-198 ; hsa-mir-130a-3p ; hsa-mir-133b ; hsa-mir-31-5p ; hsa-mir-1303 ; hsa-mir-320a ; hsa-mir-27a-3p ; hsa-mir-137 ; hsa-mir-410-3p ; hsa-mir-148a-3p ; hsa-mir-449c-5p ; hsa-mir-409-3p ; hsa-mir-101-3p ; hsa-mir-144-3p ; hsa-mir-7515 ; hsa-mir-218-5p ; hsa-mir-433-3p ; hsa-mir-139-5p ; hsa-mir-27b-3p ; hsa-mir-34a-3p ; hsa-mir-1-5p ; hsa-mir-144-5p ; hsa-mir-1257 ; hsa-mir-1262 ; hsa-mir-425-5p ; hsa-mir-4506 ; hsa-mir-4701-3p ; hsa-mir-545-5p ; hsa-mir-6736-5p ; hsa-mir-802

Nearest miRNA

hsa-mir-10525/Upstream/2022695; hsa-mir-10399/Downstream/344061;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/3718, chr7-CpG: 69/Downstream/186223

Nearest cancer related gene

MET(OG, No orient, 0)

Upstream sequence

agagtctctaaagactgggcttagaagtgccataacattacatctacggcattccattgggcagagaaagccacaagacaagcccagagttaaacagagg

Downstream sequence

ATATTTCTCTCTGTGATTGCATAAATGTGTGCAAGTATGTTTATGTAGGTTACTCCCATTGATTTTAATTTCTATAATAAATTATGTAGCTATAGGGCCC