Basic Information
VIS ID
TVIS10010883
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2197
Orient
-
Integrated sequence
ATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGC| |AACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTA
Host Sequence
Chromosome
chr7
Cytoband
q31.33
Reference genome
GRCh37/hg19
Start
125937166/126297112 (Hg38)
End
125937166/126297112 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/9276793; hsa-mir-10399/Downstream/760976;
Nearest TSS
ENST00000635602/Upstream/379241; ENST00000488818/Downstream/81858;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1366967, chr7-CpG: 237/Downstream/954134
Nearby gene
POT1(-1367129) ; GRM8(+141486) ;
Upstream sequence
TGCACTGCACCATCGTCACTTAACACGATTTTACTTTGTTGCTGGACACATAACTCCTGCTTAAAATACTGTGGACATTGAGAACAGATTTGTATTATGC
Downstream sequence
tctttgaaaaacctgccaaaaacaagcagtgaggaaaggatctcctattctgtaaatggtgctgggaaaactgactagccatacgcagaaaactgaaact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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