Basic Information
VIS ID
TVIS10010886
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1207
Orient
+
Integrated sequence
CTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGG| |CTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGC
Host Sequence
Chromosome
chr7
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
34929631/34890019 (Hg38)
End
34929631/34890019 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1183/Upstream/2156942; hsa-mir-10399/Downstream/50741;
Nearest TSS
ENST00000635602/Upstream/231610; ENST00000605778/Downstream/49218;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/810872, chr7-CpG: 203/Downstream/146505
Nearby gene
NPSR1(-11687) ; DPY19L1(+38862) ;
Upstream sequence
CAGCTCTTTATCAACATTAACTTTTGCATAGCAAACATATATGTAACTCTCAAATGTAATTAACATAATGCAGAAAAATGTTTAATTATCCACGATCCTA
Downstream sequence
AGATCCCTCAAACCCACATAGAAAGAGGTGATTTCCTAAAGCAGAGAATGTTGAGTCAAACAAATACCACTTGTCTACTTTGATATCTAATGAAGAACTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate