Basic Information
VIS ID
TVIS10010887
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1440
Orient
+
Integrated sequence
TCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGG| |CGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTA
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
56013121/55945428 (Hg38)
End
56013121/55945428 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA7A
Nearest miRNA
hsa-mir-1183/Upstream/11063628; hsa-mir-10399/Downstream/1010357;
Nearest TSS
ENST00000635602/Upstream/32790; ENST00000443449/Downstream/6365;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/57734, chr7-CpG: 52/Downstream/6250
Nearby gene
ZNF713(-4688) ; MRPS17(+6490) ;
Upstream sequence
ATTACACATTACATTTGACGAGCACATTCTCAATCTGCGTCAGTTCAGGATCATGTGAAAGAAATTATGTTTTTACTCTCATCAAAACAAAGGAATTAAT
Downstream sequence
atgcctgtaatcccagcactttgggaggctgaggcgggcagatcatgaggtgaggagttcgagaccagccttgccaatatggtgaaactccgtctctact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate