Basic Information
VIS ID
TVIS10010888
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1452
Orient
-
Integrated sequence
TCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTG| |CGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCC
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
56013159/55945466 (Hg38)
End
56013159/55945466 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA7A
Nearest miRNA
hsa-mir-1183/Upstream/11063666; hsa-mir-10399/Downstream/1010319;
Nearest TSS
ENST00000635602/Upstream/32828; ENST00000443449/Downstream/6327;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/57772, chr7-CpG: 52/Downstream/6212
Nearby gene
ZNF713(-4726) ; MRPS17(+6452) ;
Upstream sequence
TAGTTCTTATACATTGtactatggtttgaatgtgttccctccaaaattcaggtattgatgcttgacggccaaagtaaagatattaagaggtggggtcttt
Downstream sequence
cagatcatgaggtgaggagttcgagaccagccttgccaatatggtgaaactccgtctctactaaaaatacaaaaattagccgggcatggtggtgcgcacc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate