Basic Information
VIS ID
TVIS10010889
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1012
Orient
-
Integrated sequence
CACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTT| |GGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTAC
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
57990973/57931267 (Hg38)
End
57990973/57931267 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA7A
Nearest miRNA
hsa-mir-1183/Upstream/526177; hsa-mir-10399/Downstream/5689823;
Nearest TSS
ENST00000635602/Upstream/481090; ENST00000418297/Downstream/5123164;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/61825, chr7-CpG: 167/Downstream/155157
Nearby gene
ZNF716(-457708) ;
Upstream sequence
TTTCATTTCCTTCCAGGCTTAACTAAACTTTCCCTTCCTTTATAAATACTTCCTTTATAGCCCCTAAAGGTATTTTGCTTCTTTTTGTAACACAATACCA
Downstream sequence
cacatcacaaagaagtttctcagaatgcttctgtgtagtttttatgtgaagatatttccttttccacaatacgcttcaaagcactccttatatccacttg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate