Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010892
Fusion event
HBV-TPST1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2123
Orient
+
Integrated sequence
CCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGT| |TAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGT
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
Start
End
65793844/66328857 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-1183/Upstream/1649681; hsa-mir-10399/Downstream/785465;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/123218, chr7-CpG: 57/Downstream/47897
Upstream sequence
aatggttttcttaactctttggggcatagtttcaATAGCTTGGCTTTATTTTTCTGATTGAGGCAGATAAACATATTAAGTAGATAAAGATTTTCAATGT
Downstream sequence
cgctctctctctctctctctctctctctctatatatatatatatatatatttttttttttttttttttttttgagacagggtctcattctgtcacccagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.