Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010893
Fusion event
HBV-CCDC146 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|Polymerase|
Start
1379
Orient
-
Integrated sequence
ACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGG| |CTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGG
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
Start
End
76835259/77205942 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10525/Upstream/1290673; hsa-mir-10399/Downstream/14998073;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/83865, chr7-CpG: 111/Downstream/209581
Upstream sequence
atggttttcttaactctttggggcatagtttcaATAGCTTGGCTTTATTTTTCTGATTGAGGCAGATAAACATATTAAGTAGATAAAGATTTTCAATGTG
Downstream sequence
cactaattaaatagactgcaaagtggataccagtttacagtatgagatctaaaagaaggcagaaagttgccttctttgacttcagctgggtatatatgta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.