VISDB Viral Integration Site DataBase

VIS ID

TVIS10010896

Fusion event

HBV-CDK14 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

268

Orient

+

Integrated sequence

ACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTT| |CTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGG

Chromosome

chr7

Cytoband

q21.13

Reference genome

Start

End

90492331/90863016 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-376c-3p ; hsa-mir-493-5p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-6785-5p ; hsa-mir-6883-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-4533 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-6783-5p ; hsa-mir-4419a ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6873-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-4428

Nearest miRNA

hsa-mir-10525/Upstream/14947747; hsa-mir-10399/Downstream/1340999;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/265966, chr7-CpG: 255/Downstream/401262

Nearest cancer related gene

CDK14(OG, No orient, 0)

Upstream sequence

TGAAGGAGGGGCCTGGGTTCCGGGAGCACCAGCGGTGCAACCCCGGGGGAGGCCCTGGTCTACGGCGCGGGGAGCTCAGCCAGTGCGGCAGGCGTGAGGC

Downstream sequence

aaaaGTCTTGTTTTTCTACCCTTCATTTTGAATTGTTATTGACTTGGAACATGTGAAAATAGATATCTCTCATCTGACAGTGTGCCAAAATTATAATGGT