Basic Information
VIS ID
TVIS10010902
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
42
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTG| |AGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGG
Host Sequence
Chromosome
chr8
Cytoband
q24.22
Reference genome
GRCh37/hg19
Start
135797250/134785007 (Hg38)
End
135797250/134785007 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1204/Upstream/1738426; hsa-mir-10400/Downstream/15513;
Nearest TSS
ENST00000518652/Upstream/62060; ENST00000521444/Downstream/13265;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/71795, chr8-CpG: 133/Downstream/46448
Nearby gene
ZFAT(-71958) ; MIR30B(+15513) ;
Upstream sequence
cattttaaagaaggaagaatgagacggattggctaagtgtacatattcaataggttatagtgcctccttttcgtgaaaaaaaaaaaatatatatatatat
Downstream sequence
AAAGACAGATGTTGAACTGCTGTTATAAGCAATATGTAATTTCAACTTTACTAAAGTATGAATTATTTTCTCAACATGTTTGCCAATCCCTGATATTatc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate