Basic Information
VIS ID
TVIS10010906
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
35790547/35933029 (Hg38)
End
35790547/35933029 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/5975681; hsa-mir-10400/Downstream/5338019;
Nearest TSS
ENST00000518652/Upstream/70522; ENST00000522417/Downstream/160980;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/696436, chr8-CpG: 351/Downstream/1761397
Nearby gene
UNC5D(-138366) ; KCNU1(+851295) ;
Nearest cancer related gene
UNC5D(TSG, -138366) ;
Upstream sequence
tccagtcttcttgagtgatatctctggatgtgggagtgaaccaaatgaatagcgcctgaagcgaacccctagcaaaccacagcagccctacagaggaggg
Downstream sequence
ttctagtttctcctataagaatgatttctagtataaattttggggctgtcttcctttcttcaggcacccagcctcaccaatcagaaagacaaaatttttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate