Basic Information
VIS ID
TVIS10010908
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2478
Orient
+
Integrated sequence
AACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGG| |GAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAA
Host Sequence
Chromosome
chr8
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
43832427/43977284 (Hg38)
End
43832427/43977284 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/1081009; hsa-mir-10400/Downstream/17737504;
Nearest TSS
ENST00000518652/Upstream/781116; ENST00000518278/Downstream/2844953;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/699949, chr8-CpG: 41/Downstream/2640083
Nearby gene
POTEA(-614099) ;
Upstream sequence
GATTGTGAGGTAGAAGACTCTAGTCACATTTATTGATCATTTTCTGCATGTCCCAAAATATTCTATATAAATATTGATTTCAACCTATTTCAAAAGTTAT
Downstream sequence
actatctggcagtggacattttgagctccttggggcctatgctgaaaaaggaaatatcttccgacaaaaactagacagaagcattcgcagaatcacgttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate