Basic Information
VIS ID
TVIS10010913
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1167
Orient
+
Integrated sequence
GCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGC| |CAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGAT
Host Sequence
Chromosome
chr8
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
64663171/63750613 (Hg38)
End
64663171/63750613 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/2035754; hsa-mir-10400/Downstream/628536;
Nearest TSS
ENST00000518652/Upstream/45857; ENST00000519550/Downstream/18817;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/581406, chr8-CpG: 109/Downstream/618733
Nearby gene
YTHDF3(-537825) ; LINC01289(+18817) ;
Upstream sequence
tagaacactggtacataataggtgcataacacatcttaaagttgttTAATAATAGATAAGAACCAAGAGGAAAAAGAAATAAGAAAAGATGGGGGAAAGG
Downstream sequence
AGGCTTGATTTATAAAGCGTCCTCTACGATGGGAAATAGCAGGCAGCCCTGCTGATTGTTGGCCATTTTAACAAGTCCAACCTCAGGCAAAGAATTTCCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate