Basic Information
VIS ID
TVIS10010916
Fusion event
HBV-LOC105375630 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2176
Orient
-
Integrated sequence
ATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTA| |ATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTG
Host Sequence
Chromosome
chr8
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
89400558/88388329 (Hg38)
End
89400558/88388329 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105375630
Nearest miRNA
hsa-mir-12123/Upstream/8146856; hsa-mir-10400/Downstream/2817156;
Nearest TSS
ENST00000518652/Upstream/60304; ENST00000518631/Downstream/154275;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/60077, chr8-CpG: 92/Downstream/1368978
Nearby gene
MMP16(-60841) ; RIPK2(+1369417) ;
Upstream sequence
tccagtcttcttgagtgatatctctggatgtgggagtgaaccaaatgaatagcgcctgaagcgaacccctagcaaaccacagcagccctacagaggaggg
Downstream sequence
ACTCACATGCTTGCTAACTGGGAGAGCAAAGTTATGAAACACATTTCCAAAAACAAAGAGACAAACATGATATGTATAAGAAGACAAGGATGCAATCATA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate