Basic Information
VIS ID
TVIS10010921
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
680
Orient
-
Integrated sequence
CTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTT| |ACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATC
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
104890209/102127927 (Hg38)
End
104890209/102127927 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7a-1/Upstream/3898710; hsa-mir-12126/Downstream/4473001;
Nearest TSS
ENST00000422679/Upstream/389347; ENST00000374801/Downstream/391709;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/389133, chr9-CpG: 38/Downstream/1871422
Nearby gene
GRIN3A(-389347) ; CYLC2(+867384) ;
Upstream sequence
ttttggaataggtgtggtgtggtgttgaaaaaaatgtgtattctgttgatttggggtggagagttctgtagatgtctattatgtctgcttggtgcagagc
Downstream sequence
tcttctagtgtttttatggttttaggtctaacatttaagtcttcaatccatcttgaattaagttttgtgtaaggtgtaaggaagggatccagtttcagct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate