Basic Information
VIS ID
TVIS10010922
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1526
Orient
+
Integrated sequence
TTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGG| |CGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAA
Host Sequence
Chromosome
chr9
Cytoband
p23
Reference genome
GRCh37/hg19
Start
10693110/10693110 (Hg38)
End
10693110/10693110 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-2/Upstream/4685206; hsa-let-7a-1/Downstream/7880196;
Nearest TSS
ENST00000422679/Upstream/60907; ENST00000473763/Downstream/255371;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/79777, chr9-CpG: 37/Downstream/925154
Nearby gene
PTPRD(-80387) ; TYRP1(+2000276) ;
Nearest cancer related gene
PTPRD(TSG, -80387) ; TYRP1(OG, +2000276) ;
Upstream sequence
gacaatggtttgtgacagaagtccgttcaggtttgttgacagactttagttttccttcctgtgagatgggttcagttaacgaaaactctgggaagggacc
Downstream sequence
gcttgggaggctgaggcaggagaatggcgtgaacccgggaggcggagcttgcagtgagccgagatggcgccaccgcactccagcctgggcgacagtgtga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate