Basic Information
VIS ID
TVIS10010924
Fusion event
HBV-MIR548Q integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2091
Orient
+
Integrated sequence
TCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGG| |GAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGT
Host Sequence
Chromosome
chr9
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
109749688/106987407 (Hg38)
End
109749688/106987407 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
MIR548Q
Nearest miRNA
hsa-let-7a-1/Upstream/386385; hsa-mir-12126/Downstream/2058822;
Nearest TSS
ENST00000422679/Upstream/15265; ENST00000483287/Downstream/21782;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/126485, chr9-CpG: 125/Downstream/295424
Upstream sequence
gcaataaacatacgtgtgcatgtgtctttatagcagcatgatttgtaatcctttgggtatatacccagtaatgggatggctgggtcaaatggtatttcta
Downstream sequence
tgatcattagtgatgctgagcatttttccatatgtctgttggccatctgtatctcttcttttgagaactgtctattcatgtccttagcccactttttcat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate