Basic Information
VIS ID
TVIS10010925
Fusion event
HBV-MIR3134 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
921
Orient
-
Integrated sequence
TTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAAC| |ACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGC
Host Sequence
Chromosome
chr9
Cytoband
q32
Reference genome
GRCh37/hg19
Start
114960737/112198457 (Hg38)
End
114960737/112198457 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA9E
Target gene
MIR3134
Nearest miRNA
hsa-let-7a-1/Upstream/266288; hsa-mir-12126/Downstream/2010977;
Nearest TSS
ENST00000422679/Upstream/23049; ENST00000480881/Downstream/134569;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/22913, chr9-CpG: 141/Downstream/134412
Upstream sequence
AGGAGGTATGGGTTTGAGAAATTCTACAAGTCGGAATTCTTGGCTAGGAAATTATTTGATGTCTCTTTCAGTGCTTCAGATTTGCTAGTAACCAGCTCTA
Downstream sequence
acttttctgtCTTCCTCCAGTGGTTTAAAGcagcactttccaatagacatataaggtcaggcacaaatttgagagtcatatagacttttaaattttctag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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