VISDB Viral Integration Site DataBase

VIS ID

TVIS10010928

Fusion event

HBV-FREM1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1905

Orient

+

Integrated sequence

CACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATG| |GACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCT

Chromosome

chr9

Cytoband

p22.3

Reference genome

Start

End

14742383/14742385 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-384 ; hsa-mir-7975 ; hsa-mir-5571-3p ; hsa-mir-138-1-3p ; hsa-mir-186-3p ; hsa-mir-1283 ; hsa-mir-142-3p ; hsa-mir-3529-3p ; hsa-mir-3591-5p ; hsa-mir-3618 ; hsa-mir-4678 ; hsa-mir-4761-5p ; hsa-mir-934

Nearest miRNA

hsa-mir-101-2/Upstream/8734481; hsa-let-7a-1/Downstream/3830921;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/48807, chr9-CpG: 41/Downstream/235711

Upstream sequence

GCCCTTTGTAGATGGAACACATACCTCCAGACCAGTGGTCCACAGAACACACGCTAGAAAACAATCCATTCAATCACTCTGGTACTTAGAGAAAGAAAAA

Downstream sequence

TACAATGACTGCCTGAGGAAATGAGCAGATGAGATTACAACATGTAAATTCAAGAAGTGCATAATCTAGGAGTCTGGCTCCTTTGACTTAGAAAAATAAT