Basic Information
VIS ID
TVIS10010931
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
680
Orient
-
Integrated sequence
CTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTT| |ACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATC
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
24282394/24282396 (Hg38)
End
24282394/24282396 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA9C
Nearest miRNA
hsa-mir-101-2/Upstream/2770211; hsa-let-7a-1/Downstream/4581230;
Nearest TSS
ENST00000422679/Upstream/384342; ENST00000602614/Downstream/263280;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/430872, chr9-CpG: 111/Downstream/1395100
Nearby gene
ELAVL2(-456331) ; TUSC1(+1393993) ;
Nearest cancer related gene
TUSC1(TSG, +1393993) ;
Upstream sequence
CAGTTTTGGTTTATTTGAAACCATAGATGGCTCTATTGAATAAGGATTATGAATAAGAGTGGGTTATAGTAGAGTAGGTGATGAATTGTGAAGTTTTGTG
Downstream sequence
acctagacaataccattcaggacataggcatgggcaaggacttcatgtctaaaacaccaaaagcaatggcaacaaaagccaaaattgacaaatgggatct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate