VISDB Viral Integration Site DataBase

VIS ID

TVIS10010944

Fusion event

HBV-IKBKG integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1827

Orient

-

Integrated sequence

AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT

Chromosome

chrX

Cytoband

q28

Reference genome

Start

End

153783610/154555395 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRAXE ; FRAXF

Target gene

miRNAs that regulate target gene

hsa-mir-15a-5p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6878-5p ; hsa-mir-4306 ; hsa-mir-4644 ; hsa-mir-185-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4784 ; hsa-mir-4419a ; hsa-mir-3150b-3p ; hsa-mir-6760-5p ; hsa-mir-6873-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-513b-5p ; hsa-mir-8056 ; hsa-mir-4320 ; hsa-mir-338-5p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-5580-3p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-1284 ; hsa-mir-665 ; hsa-mir-2054 ; hsa-mir-6771-5p ; hsa-mir-7160-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-6746-5p ; hsa-mir-488-5p ; hsa-mir-6500-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-5582-5p ; hsa-mir-887-3p ; hsa-mir-3162-5p ; hsa-mir-4722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-342-3p ; hsa-mir-708-5p

Nearest miRNA

hsa-let-7f-2/Upstream/105009; hsa-mir-1184-1/Downstream/213201;

Nearest TSS

Nearest CpG islands

None/Target, chrX-CpG: 62/Upstream/7474, chrX-CpG: 29/Downstream/4924

Upstream sequence

agtggaactccagcaaactccaacagacctacagctgagggtcctgtctgttagaaggaaaactaacaaacagaaaggacatccacaccaaaaacccatc

Downstream sequence

TCGAGTCACTTACAAACAAAGTGGCATAAggccaggcacagtggcccatgcctataatcccagcactttcggaggccgaggtgggaggattgcttgaggc